https://www.ceesdekker.net Secrets

Midway through his job, Cees Dekker reinvented himself. Following yrs of hardcore physics, he shifted his concentrate to ‘nanobiology’ for the flip with the millennium. A term he coined himself, being a make a difference of actuality.

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Nanofabrication of electrodes with sub-5 nm spacing for transportation experiments on single molecules and steel clusters

2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and first at any time study with the dynamics DNA supercoils and the discovery of supercoil hopping

The coiled-coil on the human Rad50 DNA restore protein incorporates precise segments of elevated adaptability

Because 2000 he moved to one-molecule biophysics and nanobiology, with investigate from DNA supercoiling scientific tests of nucleosomes and DNA mend proteins to DNA translocation by means of nanopores. Lately his research has centered on learning cell division ceesdekker with microbes on chip, even though his final interest is during the route of recognizing artificial cells.

2000, discovery that nanotubes can have extraordinary massive current densities; settled the controversial challenge of electronic transport by DNA molecules by measurements of insulating behavior at The only molecule stage; and demonstration of the AFM method for solitary-molecule manipulation of nanotubes

In 1993, like a younger and keen associate professor at Delft University of Technological innovation, I'd at first targeted the investigate efforts of my group on measuring the electrical conductance of an individual conducting-polymer molecule. In just two many years, we had made a tool in which just one wire of the phthalocyaninepolysiloxane polymer was linked concerning two closely spaced metal nanoelectrodes.

Resolving the action dimensions in condensin-pushed DNA loop extrusion identifies ATP binding since the phase-creating approach

An integrated microfluidic platform for quantifying drug permeation throughout biomimetic vesicle membranes

1999, to start with measurement in the wavefunction of one molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for your new Luttinger description of interacting electrons in nanotubes

2005, discovery in the system of DNA uncoiling by topoisomerase enzymes; discovery of lengthy-vary conformational adjustments in Mre11/DNA maintenance complexes; and very first pressure measurements on a DNA molecule in the nanopore

It had been an exceedingly intriguing time, through which I received a great deal of aid from Delft University of Technological innovation, where by I was a professor at time, and I started off several collaborations with molecular biologists. That helped me understand quite a bit.’

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