Nanotechnology gives A selection of prospects to add to biology. In this article I'll present examples in which nanofabrication – the opportunity to make confined buildings with Proportions at will – is applied to look at the biophysics of one molecules and cells. I'll current some illustrations from our lab:
Our group scientific studies bacterial cell division and is particularly aiming to represent a ‘bottom up biology’ in synthetic cells which can autonomously divide. Our main desire lies in cell division, chromatin structure, and spatial control.
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Given that 2000, Dekker has shifted the leading concentrate of his get the job done in direction of biophysics where by he research the Homes of one biomolecules and cells utilizing the tools of nanotechnology. This variation of subject was pushed by his fascination for the impressive operating of Organic molecular buildings, in addition to with the very long-time period perspective that a lot of intriguing discoveries is usually expected Within this discipline.[5] Recent lines of study in his biophysics team are during the parts of:[six]
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Direct immobilization of native yeast iso-one cytochrome c on bare gold: rapid electron relay to redox enzymes and zeptomole protein-film voltammetry
Since 2000 he moved to one-molecule biophysics and nanobiology, with exploration from DNA supercoiling reports of nucleosomes and DNA fix proteins to DNA translocation by way of nanopores. Not too long ago his research has centered on learning cell division with micro organism on chip, even though his greatest desire is while in the path of knowing artificial cells.
Atomic pressure microscopy reveals that vaccinia topoisomerase IB generates filaments on DNA inside a cooperative trend
Knowledge essential procedures regulating the spatial and dynamic organisation ceesdekker with the DNA in Stay cells.
Dekker began his research on solitary carbon nanotubes in 1993 when he setup a completely new line of investigation to study electrical transportation by means of one organic and natural molecules in between nanoelectrodes. In 1996 a breakthrough was understood with carbon nanotubes. This was attained inside of a collaboration Together with the group of Nobel laureate Richard Smalley. STM and nanolithography approaches had been utilized to show that these nanotubes are quantum wires at The one-molecule level, with outstanding Bodily properties.
[14] In 2005 Dekker grew to become linked to Netherlands-vast discussions about Intelligent Design and style, a movement that he has due to the fact Obviously distanced himself from. Dekker advocates that science and faith are not in opposition but might be harmonized.
Nanoscientist Cees Dekker is really an amiable and flamboyant gentleman who appears much young in comparison to the 62 many years he actually is – modern glasses, psychedelic shirt, engaging smile – although not a single to waste time. He usually takes his time, but not more than important.
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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij met enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond smart style and design in 2005. (nl)